Translationnal research

The research conducted at GIGA-R concerns life sciences and aims at a better understanding of the structure and functioning of the human being. Many researchers in GIGA-R come from faculties where health sciences are studied (Faculty of Medicine and Faculty of Veterinary Medicine) and much of the work is dedicated to human dysfunction, i.e. disease.

This research improves the level of knowledge, but we also hope that it will contribute to improved understanding of disease and hence, better detection, diagnosis and treatment. The transfer of fundamental research results into medical practice has often been by chance; this is how much progress in medicine has been made. Today’s challenges in medicine are more and more demanding; it’s obvious that is not by chance that it will be possible to cure the last 10-20% of acute leukemias which are still refractory to currently available treatments; indeed we must strive to improve our understanding of the diseases and, based on new information gathered, devise new treatments; this translation of discoveries of advanced fundamental research for the benefit of patients is now called “translational research”.

We have identified close to 200 research projects that fulfil  the criteria of translational research. You can find a non-exhaustive list of themes of this research below.

We must point out that several recent initiatives aim to emphasise the efforts made on transitional research. We should mention the federal government’s Cancer Plan which supports 5 projects carried out with the collaboration of CHU clinicians and GIGA-R researchers in Liege. The themes of these projects are glioblastoma, cervical cancers, non-Hodgkin’s lymphoma, tumor angiogenesis and mesenchymal cells.

 

IMMUNOLOGY AND INFLAMMATION

- Bowel inflammatory diseases (Crohn: genetics, mechanisms, biomarkers, new treatments)
- Animal model for the study of immunomodulation in HIV+ patients
- Interstitial macrophages
- Rheumatic diseases (biomarkers, new treatments)
- Chronic rhinosinusitis (biomarkers)

CARDIOVASCULAR SYSTEM

- Cardiac remodeling (biomarkers)
- Cardiac valves (coronary artery diseases, myxoid dégénération)
- Artherosclerosis ( mechanisms, biomarkers, aneurysms)
- Myocardial infarction (biomarkers)
- Arterial thrombosis (new treatments)

CANCERS

- Biomarkers in oncology : hepatic metastases, prostate cancer, DNA methylation, colon cancers
- Angiogenesis and extracellular matrix (mechanisms, in vivo imaging, new treatments)
- Breast cancer (interactions with skin adipocytes, mTOR inhibitors)
- Cancer of the uterine cervix (role of the local immunity)
- Epithelial metaplasia
- Leukemia : new approaches (stem cells, cord blood, mini-transplants, immunotherapy, mesenchymal stem cells, iron metabolism, graft versus host disease, ZAP70 in lymphoid leukemia)
- Non-Hodgkin lymphomas (miRNA, T cell lymphoma)
- Myeloma (proteases, new treatments)
- Glioblastoma (cancer stem cells, intelligent drugs)

NEUROSCIENCES

 - Parkinson’s disease (biomarkers)
 - Alzheimer’s disease (new treatments)
 - Brain and sexual development

 ENDOCRINOLOGY AND UROGENITAL SYSTEM

 - Type 1 diabetes (Lymphoid tyrosine phosphatase)
 - Endometrium, Endometriosis
 - Ovarian cryopreservation
 - Pituitary adenomas

MUSCULOSKELETAL SYSTEM

 - Cartilage biomarkers in childhood
 - Stem cells in muskuloskeletal diseases
 - Tendon healing process

 GENETIC

 - Genetic diseases (mucoviscidosis, pituitary adenoma)

EXTRACELLULAR MATRIX AND ANGIOGENESIS (except cancers)

 - Ophtalmology (age-related macular degeneration)
 - Dermatology (psoriasis, skin ulcers)
 - Otolaryngology (vocal cords)