Marichal Thomas, DVM, PhD

Principal Investigator
Email - +32 4 366 95 55

Dr. Thomas Marichal graduated in 2007 as a Doctor in Veterinary Medicine from the University of Liège (BE). He obtained a PhD in Immunology in June 2011, under the supervision of Prof Fabrice Bureau (Laboratory of Cellular and Molecular Immunology, GIGA-Research Institute, University of Liege, BE) and was awarded a Marie Curie International Outgoing Fellowship from the European Commission for a postdoctoral training at Stanford University (California, USA), with Prof Stephen J. Galli as a mentor. Since 2014, he is back as a junior principal investigator at the GIGA-Research Institute in Liege (BE), thanks to a "Chargé de recherches" fellowship of the F.R.S.-FNRS.

 

Research topic

Dr. Marichal's current research activity is mainly interested in the complex regulation of macrophage and epithelial cell functions, which maintain homeostasis at cutaneous and mucosal surfaces and can prevent the development of type 2 immune-mediated diseases such as atopic dermatitis, food allergy or allergic asthma. 

 

Awards and prizes

Dr. Marichal has published several original articles, among others in The Journal of Clinical Investigation (2009), The Journal of Allergy and Clinical Immunology (2010, 2015), Nature Medicine (2011) and Immunity (2013). His early achievements have been rewarded by several awards, among others the 2013 D. and M. Jaumain Foundation Award (Leon Fredericq Foundation), the 2014 European Allergy Research Award and the 2015 ACTERIA Early Career Research Prize in Allergology.

 

Selected publications

 

1) IgE antibodies, FceRIa, and IgE-mediated local anaphylaxis can limit snake venom toxicity. P. Starkl, T. Marichal (co-first author), N. Gaudenzio, L.L. Reber, R. Sibilano, M. Tsai, SJ. Galli. J Allergy Clin Immunol. 2015, In press. 

 

2) A beneficial role for Immunoglobulin E in host defense against honeybee venom. T. Marichal, P. Starkl (co-first author), LL. Reber, J. Kalesnikoff, HC. Oetggen, M. Tsai, M. Metz, SJ. Galli. Immunity. 2013, 39(5):963-75. 

 

Comments in:

"A sting in the tale of TH2 immunity", Immunity, 2013;

"Antibodies: taking the sting out", Nat. Rev. Immunol., 2013.

 

3) DNA released from dying host cells mediates aluminum adjuvant activity. T. Marichal, K. Ohata, D. Bedoret, C. Mesnil, C. Sabatel, K. Kobiyama, P. Lekeux, C. Coban, S. Akira, K. J. Ishii, F. Bureau, C. J. Desmet. Nat. Med. 2011, 17:996-1002.

 

4) Interferon Response Factor-3 is essential for house dust mite-induced airway allergy. T. Marichal, D. Bedoret, C. Mesnil, M. Pichavant, S. Goriely, F. Trottein, D. Cataldo, M. Goldman, P. Lekeux, F. Bureau, C.J. Desmet. J. Allergy Clin. Immunol. 2010, 126:836-844.