Meet the zebrafish

Zebrafish (Danio Rerio) have emerged as one of the leading model for studying the development and modeling of human disease. 

 

These little teleost fish present many advantages:

  • very rapid embryonic development (all major organs are formed within 3 days)
  • transparency of the embryos (allowing visual observations of internal structures and non-invasive imaging)
  • short generation time (zebrafish are sexually mature after 3-4 months)
  • high fecundity (a single female can lay up to 150  eggs per clutch et per week allowing powerful statistics)
  • high genetic homology to humans (about 75% of the human genome has functional homologs with zebrafish)

 

The use of zebrafish has attracted researchers from various fields and has been applied in several areas of research:

  • Clinical research gastrointestinal disorders, muscle diseases, complex brain disorders, cancers and many other diseases can be modeled in zebrafish
  • Developmental processes
  • Drug discovery and screening
  • Neuroscience
  • Cardiovascular research
  • Wound healing
  • Microbe-host interactions
  • Behavior genetics
  • Toxicology