Publications représentatives

NGS-based reverse genetic screen for embryonic lethal mutations compromising fertility in livestock.

Charlier C, Li W, Harland C, Littlejohn M, Coppieters W, Creagh F, Druet T, Faux P, Guillaume F, Karim L, Keehan M, Davis S, Kumar-Kadri N, Spelman R, Georges M

Under revision.

 

HTLV-1/BLV antisense RNA-dependent cis-perturbation of cancer drivers in leukemic and pre-leukemic clones.

Rosewick N, Durkin K, Marçais A, Artesi M, Hahaut V, Griebel P, Arsic N, Avettan-Fenoel V, Burny A, Charlier C, Hermine O, Georges M, Van den Broeke.

Under revision.  

 

Association mapping of inflammatory bowel disease loci to single variant resolution.

Huanh H, Fang M, Jostins L, Umicevic Mirkov M, Boucher G, ANderson CA, Andersen V, Cleynen I, Cortes A, Crins F, D'Amato M, Deffontaine V, Dmitrieva J, Docampo E, Elansary M, Kai-How Farh K, Franke A, Gori A-S, Goyette P, Halfvarson, Haritunians T, Knight J, Lawrance IC, Lees CW, Louis E, Mariman R, Meuwissen T, Mni M, Momozawa Y, Parkes M, Spain SL, Theatre E, Trynka G, Satsangi J, van SOmmeren S, Vermeire S, Xavier RJ, IIBDGC, Weersma R, Duerr RH, Mathew CG, Rioux JD, McGovern DPB, Cho JH, Georges M, daly M, Barrette JC.

Under revision.

 

Serial translocation via circular intermediates underlies color-sidedness in cattle.

Durkin K, Coppieters W, Drögemüller C, Ahariz N, Cambisano N, Fasquelle C, Haile A, Horin P, Huang L. Karim L, Moser S, Oldenbroek K, Rieder S, Sartelet A, Solkner J, Stalhammer H, Leeb T, Georges M, Charlier C.

Nature 482: 81-84 (2012).News & Views.

 

Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature.

Karim L, Takeda H, Lin L, Druet T, Arias JAC, Baurain D, Cambisano N, Davis SR, Farnir F, Grisart B, Harris BL, Keehan MD, Littlejohn MD, Spelman RJ, Georges M, Coppieters W. 

Nature Genetics 43: 405-413 (2011).

 

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease.

Momozawa Y, Mni M, Nakamura K, Coppieters W, Almer S, Amininejad L, Dewit O, Finkel Y,Gassuli MA, Goossens D, Laukens D, Lémann M, Libioulle C, O'Morain C, Reenaers C, Rutgeerts P, Tysk C, Zelenika D, Lathrop M, Del-Favero J, Hugot JP, de Vos M, Franchimont D, Vermeire S, Louis E, Georges M. 

Nature Genetics 43:43-47 (2011) 

 

CDC39 is required for assembly of inner dynein arms and the dynein regulatory complex as well as normal ciliary motility in human and dogs. 

Merveille AC, Davis E, Becker-Heck A, Legendre M, Amirav I, Bataille G, Belmont J, Beydon N, Billen F, Clément A, Clercx C, Coste A, Crosbie R, de Blic J, Deleuze S, Duquesnoy P, Escalier D, Escudier E, Fliegauf M,  Horvath J, Hill K,Jorissen M, Just J, Kispert A, Lathrop M, Tomas Loges N, Marthin JK,  Momozawa Y, Montantin G, Nielsen KG, Olbrich H, Papon JF, Rayet I, Roger G, Schmidts M, Tenreiro H, Towbin JA, Zelenika D, Zentgraf H, Georges M, Lequarré AS, Katsanis N, Omran H, Amselem S. 

Nature Genetics 43:72-78 (2011) 

 

Highly effective SNP-based association mapping and management of recessive defects in livestock.

Charlier C, Coppieters W, Rollin F, Desmecht D, Agerholm JS, Cambisano N, Carta E, Dardano S, Dive M, Fasquelle C, Frennet JC, Hanset R, Hubin X, Jorgensen C, Karim L, Kent M, Harvey K, Pearce BR, Simon P, Tama N, Nie H, Vandeputte S, Lien S, Longeri M, Fredholm M, Harvey RJ, Georges M.

Nature Genetics 40:449-454 (2008)

 

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep.

Clop A, Marcq F, Takeda H, Pirottin D, Tordoir X, Bibé B, Bouix J, Caiment F, Elsen JM, Eychenne F, Larzul C, Laville E, Meish F, Milenkovic D, Tobin J, Charlier C, Georges M.

Nature Genetics 38:813-818 (2006)

 

The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.

Charlier C, Segers K, Karim L, Shay T, Gyapay G, Cockett N, Georges M.

Nat Genet 27:367-369 (2001).