Publications significatives

Close P, East P, Dirac-Svejstrup AB, Hartmann H, Heron M, Maslen S, Chariot A, Söding J, Skehel M, Svejstrup JQ.

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.

Nature. 2012;484(7394):386-9.

 

Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S.

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.

J Clin Invest. 2010 ;120(8):2910-9.

 

Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L.

Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin.

Cell. 2009;136(3):551-64.

 

Musumeci L, Kuijpers MJ, Gilio K, Hego A, Théâtre E, Maurissen L, Vandereyken M, Diogo CV, Lecut C, Guilmain W, Bobkova EV, Eble JA, Dahl R, Drion P, Rascon J, Mostofi Y, Yuan H, Sergienko E, Chung TD, Thiry M, Senis Y, Moutschen M, Mustelin T, Lancellotti P, Heemskerk JW, Tautz L, Oury C, Rahmouni S.

Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.

Circulation. 2015;131(7):656-68.

 

Shostak K, Zhang X, Hubert P, Göktuna SI, Jiang Z, Klevernic I, Hildebrand J, Roncarati P, Hennuy B, Ladang A, Somja J, Gothot A, Close P, Delvenne P, Chariot A.

NF-κB-induced KIAA1199 promotes survival through EGFR signalling.

Nat Commun. 2014;5:5232.

 

Specific and non-hepatotoxic degradation of nuclear hepatitis B virus cccDNA

Julie Lucifora1,2,*, Yuchen Xia1,*, Florian Reisinger1, Ke Zhang1, Daniela Stadler1, Xiaoming Cheng1, Martin Sprinzl1,3, Herwig Kloppensteiner1, Zuzanna Makowska4, Tassilo Volz5, Caroline Remouchamps6, Wen-Min Chou1, Wolfgang Thasler7, Norbert Hüser8, David Durantel9, Carsten Münk10, Markus H. Heim4, Jeffrey L. Browning11, Emmanuel Dejardin6, Maura Dandri5,2, Michael Schindler1, Mathias Heikenwalder1# and Ulrike Protzer

Science, 2014; 343(6176):1221-8

        

Non-canonical NF-kB signaling is limited by classical IKK activity and dysregulated in NEMO-ID

Carolyn Gray, Caroline Remouchamps, Kelly A. McCorkell, Laura A. Solt, Emmanuel Dejardin, Jordan S. Orange and Michael May

Science Signaling, 2014 ; 7(311) :ra13

 

Peixoto P, Castronovo V, Matheus N, Polese C, Peulen O, Gonzalez A, Boxus M, Verdin E, Thiry M, Dequiedt F, Mottet D.

HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells.

Cell Death Differ. 2012 Jul;19(7):1239-52.

 

Mottet D, Pirotte S, Lamour V, Hagedorn M, Javerzat S, Bikfalvi A, Bellahcène A, Verdin E, Castronovo V.

HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism.

Oncogene. 2009 Jan 15;28(2):243-56.

 

Martin M, Geudens I, Bruyr J, Potente M, Bleuart A, Lebrun M, Simonis N, Deroanne C, Twizere JC, Soubeyran P, Peixoto P, Mottet D, Janssens V, Hofmann WK, Claes F, Carmeliet P, Kettmann R, Gerhardt H, Dequiedt F.

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.

EMBO J. 2013;32(18):2491-503.

 

Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M.

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.

Nature. 2011;473(7346):234-8.

 

Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M.

A proteome-scale map of the human interactome network.

Cell. 2014;159(5):1212-26.

 

Simonis N, Rual JF, Lemmens I, Boxus M, Hirozane-Kishikawa T, Gatot JS, Dricot A, Hao T, Vertommen D, Legros S, Daakour S, Klitgord N, Martin M, Willaert JF, Dequiedt F, Navratil V, Cusick ME, Burny A, Van Lint C, Hill DE, Tavernier J, Kettmann R, Vidal M, Twizere JC.

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.

Retrovirology. 2012;9:26.

 

Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Musumeci L, Francis D, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L.

LYP inhibits T-cell activation when dissociated from CSK.

Nat Chem Biol. 2012;8(5):437-46.

 

Molina-Ortiz P., Polizzi S., Ramery E., Gayral S., Delierneux C., Oury C.,

Iwashita S., and Schurmans S

Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and  differentiation into proplatelet. PLOS Genetics. 2014;10(6) e1004420.

 

Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, Kayserili H, Swistun D, Scott LC, Bertini E, Boltshauser E, Fazzi E, Travaglini L, Field SJ, Gayral S, Jacoby M, Schurmans S, Dallapiccola B, Majerus PW, Valente EM, Gleeson JG.

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.

Nat Genet. 2009;41(9):1032-6.